How is intrapleural chemotherapy typically administered?

Intrapleural chemotherapy is administered directly into the pleural space, typically using a thoracotomy tube. This method allows for localized treatment of malignancies that involve the pleural cavity, such as mesothelioma or metastatic cancers, where the primary challenge is often fluid accumulation and disease spread in this area.

By delivering chemotherapy directly into the pleural space, higher concentrations of the drug can be achieved in the targeted area while potentially reducing systemic side effects. This method is specifically designed to address conditions where the cancer is present in the pleural lining rather than in the bloodstream or throughout the body.

The other options refer to methods of administration that are not suitable for intrapleural chemotherapy. Central lines and IV catheters are primarily used for systemic chemotherapy treatments, delivering drugs into the bloodstream, while delivering treatment via a thoracotomy tube is the preferred approach for localized therapy within the pleura.