Rituximab should not be administered to patients with what condition?

Rituximab is a monoclonal antibody primarily used to treat certain types of cancers and autoimmune diseases. However, its administration is contraindicated in patients with severe cardiac conditions. This is due to the potential for serious infusion-related reactions that can exacerbate existing cardiovascular issues. These reactions may include hypotension, arrhythmias, and other cardiac complications, which can be particularly risky for patients with pre-existing cardiac problems.

While other conditions like hypertension, kidney disease, and diabetes require careful consideration and management when administering various medications, they do not carry the same level of risk as severe cardiac conditions when it comes to rituximab. Therefore, patients with significant heart issues should be approached with caution or potentially excluded from receiving this treatment to ensure their safety.