When administering cyclophosphamide, what is an essential nursing consideration?

When administering cyclophosphamide, ensuring patient hydration to prevent hemorrhagic cystitis is a crucial nursing consideration. Cyclophosphamide is associated with the risk of causing hemorrhagic cystitis, a potential complication characterized by inflammation and bleeding in the bladder. This effect occurs because cyclophosphamide is metabolized to acrolein, a toxic byproduct that can irritate the bladder lining. To mitigate this risk, it is vital to encourage adequate fluid intake, which helps to flush out the bladder and dilute the urinary concentration of acrolein. This hydration strategy significantly reduces the likelihood of bladder irritation and subsequent complications.

Other considerations related to cyclophosphamide administration include monitoring for side effects such as nausea, vomiting, and bone marrow suppression, but the specific focus on hydration as a preventative measure for hemorrhagic cystitis is particularly important in this context.