Which cancer types are treated with Irinotecan?

Irinotecan is primarily used in the treatment of colorectal cancer, making it a key component of the chemotherapy regimens aimed at managing this disease. It functions as a topoisomerase I inhibitor, disrupting DNA replication and leading to cancer cell death. This is particularly effective for colorectal cancer, where it is often used in combination with other agents to enhance its therapeutic effects.

Esophageal cancer is another type where irinotecan has shown efficacy, particularly in cases where the disease has progressed or is recurrent. The drug's ability to target rapidly dividing cells makes it suitable for managing cancers such as esophageal carcinoma.

Other options, like ovarian and breast cancers or brain and lymphoma cases, typically utilize different chemotherapeutic agents that are better suited for those specific tumors. Each cancer type has distinct biological behaviors and treatment protocols, which helps guide the choice of chemotherapy. In summary, irinotecan's established role in the treatment of colorectal and esophageal cancer underlines its selection as the correct option.